Yajun Yan Professor of Biochemical Engineering, School of Chemical, Materials and Biomedical Engineering Director, Biosynthetic Engineering and Biocatalysis Laboratory Professor Yajun Yan received his Bachelor's and Master's degrees in Biochemical Engineering from Beijing University of Chemical Technology in 1999 and 2002 respectively. He then obtained his PhD in Chemical and Biological Engineering from the State University of New York at Buffalo in 2008. From 2008 to 2010, he worked as a postdoctoral researcher in Synthetic Biology and Metabolic Engineering at the University of California, Los Angeles. Since 2010, he has been a faculty member at the University of Georgia, where he was promoted to tenured Associate Professor in 2015 and to full Professor in 2019.Professor Yajun Yan has a broad academic background in Chemical and Biological Engineering. Over the past 20 years, his research has focused mainly on Synthetic Biology and Metabolic Engineering. He is dedicated to developing microbial and enzymatic methods for efficient production of biofuels, bulk and fine chemicals, natural products, and drug-active molecules. His research projects cover multiple disciplines, including Biochemistry, Microbiology, Molecular Biology, Protein Engineering, Metabolic Engineering, and the principles and techniques of Synthetic Biology. His AI-related research interests include applying AI techniques to design and engineer biological systems. These systems can be enzymes, metabolic pathways, metabolic regulations, genetic circuits and even whole organisms. In addition, he is interested in utilizing AI to identify potential drug candidates, optimize production pathways, and improve the yields of bio-based products.To date, Professor Yajun Yan has published over 110 academic papers in prestigious journals in his field, such as Nature Biotechnology, Nature Communications, PNAS, Trends in Biotechnology, Biotechnology Advances, Metabolic Engineering, Green Chemistry, ACS Synthetic Biology, etc. He has also co-authored three academic books and holds 16 patents in multiple countries including the US, China, and Canada. Education: Ph.D., Chemical and Biological Engineering, University of Buffalo, 2008 M.S., Biochemical Engineering, Beijing University of Chemical Technology, 2002 B.S., Biochemical Engineering, Beijing University of Chemical Technology, 1999 Research Research Interests: Metabolic Engineering Synthetic Biology Protein Engineering Natural Products Biofuels and Renewable Chemicals Read more about Yajun Yan
Natarajan Kannan Distinguished Research Professor of Biochemistry & Molecular Biology and the Institute of Bioinformatics Georgia Cancer Coalition Distinguished Scholar The Kannan Lab is interested in developing and applying deep learning and machine learning models for bioinformatics applications. Ongoing funded projects are focused on applying large language models for protein function prediction, classification, and text mining. The lab is also interested in representation learning on knowledge graphs, contrastive learning, and generative diffusion models for protein design and dynamics. If you are interested in any of these areas, please contact Dr. Kannan (nkannan@uga.edu) with a statement of research interest and a CV. Education: Georgia Cancer Coalition Distinguished Cancer Scholar Cold Spring Harbor Laboratory, New York, Postdoc University of California, San Diego, Postdoc Indian Institute of Science, Bangalore, Ph.D., 2001 Research Research Interests: Machine learning for bioinformatics Protein sequence, structure, and function analysis Evolutionary and systems biology approaches AI models for protein design and classification Selected Publications Selected Publications: Zhou Z, Yeung W, Soleymani S, Gravel N, Salcedo M, Li S, Kannan N. Using explainable machine learning to uncover the kinase-substrate interaction landscape. Bioinformatics. 2024 Feb 1;40(2):btae033. doi: 10.1093/bioinformatics/btae033. PMID: 38244571; PMCID: PMC10868336 Yeung W, Zhou Z, Li S, Kannan N. Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings. Brief Bioinform. 2023 Jan 19;24(1):bbac599. doi: 10.1093/bib/bbac599. PMID: 36631405; PMCID: PMC9851297. Taujale R, Zhou Z, Yeung W, Moremen KW, Li S, Kannan N. Mapping the glycosyltransferase fold landscape using interpretable deep learning. Nat Commun. 2021 Sep 27;12(1):5656. doi: 10.1038/s41467-021-25975-9. PMID: 34580305; PMCID: PMC8476585. Salcedo MV, Gravel N, Keshavarzi A, Huang LC, Kochut KJ, Kannan N. Predicting protein and pathway associations for understudied dark kinases using pattern-constrained knowledge graph embedding. PeerJ. 2023 Oct 18;11:e15815. doi: 10.7717/peerj.15815. PMID: 37868056; PMCID: PMC10590106. Read more about Natarajan Kannan
Yaguang Xi Professor and Department Head, Department of Pharmaceutical & Biomedical Sciences UGA Athletic Association Distinguished Professor in Pharmacy and Pharmaceutical Sciences Dr. Xi previously practiced as a surgeon before pursuing graduate studies for a PhD in cell biology. Currently, his research programs, supported by multiple NIH R01 grants, focus on cancer drug development, specifically targeting metastatic breast cancer and colorectal cancer. Dr. Xi possess extensive teaching and mentoring experience across various levels, including undergraduate students, graduate students, medical students, postdoctoral fellows, and junior faculty members. Many of his trainees have successfully established independent careers. Dr. Xi’s current research interest lies in the intersection of AI and biomedical research, particularly AI's role in cancer drug development. Since joining UGA as the Department Head of Pharmaceutical and Biomedical Sciences at the College of Pharmacy in August 2023, he is keen on expanding his focus to AI and biomedical research. Education: M.D. Inner Mongolia Medical University, 1996 Ph.D. Peking University, 2003 M.B.A. University of South Alabama, 2012 Research Research Interests: Cancer drug discovery and development Molecular mechanisms of cancer initiation, progression, and metastasis MicroRNA-mediated mechanisms in NSAID-based cancer prevention and therapy Immunotherapy and immune modulation in breast and colorectal cancer Cancer therapeutics, chemoprevention, and health disparities Read more about Yaguang Xi
Y. George Zheng Panoz Professor of Pharmacy, Pharmaceutical and Biomedical Sciences Professor Y. George Zheng is a Full Professor in the Department of Pharmaceutical and Biomedical Sciences at University of Georgia. Dr. Zheng’s research interests are mainly focused on developing innovative pharmacological molecules for the treatment of cancer and metabolic diseases. Prof. Zheng’s laboratory has the expertise in the area of in silico drug screening, molecular docking, structure-based drug design, and medicinal chemistry. He has published more than 100 peer-reviewed papers in the leading journals such as Nature, Nature Communications, Nucleic Acid Research, Angewandte Chemie, Journal of American Chemical Society, Journal of Medicinal Chemistry, etc. He has been supervising undergraduate students, Masters and doctoral graduate students, and postdoctoral trainees. The group welcomes students who have molecular science foundation with sincere enthusiasm to create next blockbuster drugs for curing human diseases. Education: Postdoctoral Training Pharmacology, The Johns Hopkins University 2006 Ph.D. Chemistry, University of Miami, Florida 2002 M.S. Chemistry, Peking University, Beijing, China 1998 B.S. Chemistry, Peking University, Beijing, China 1995 Research Research Interests: Medicinal chemistry, protein biochemistry, and chemical biology Drug discovery and development for cancer and metabolic diseases Epigenetics and epigenetic regulation in human disease Protein post-translational modifications and their roles in disease mechanisms Chemical probes and structure-based approaches for targeting epigenetic enzymes Read more about Y. George Zheng
Matthew Schmidt Professor, Department of Workforce Education and Instructional Technology Matthew Schmidt, Ph.D., is Associate Professor at the University of Georgia (UGA) in the Learning, Design, and Technology department. His primary research interest includes design and development of innovative educational courseware and computer software with a particular focus on individuals with disabilities, their families, and their providers. His secondary research interests include learning in extended reality (inclusive of virtual reality, augmented reality, and mixed reality) and Learning Experience Design. Education: Ph.D. in Information Science and Learning Technologies from the University of Missouri Research Research Interests: Learning Experience Design Learning in extended reality (VR, AR, MR) Machine learning and artificial intelligence for learning Design and development of educational courseware Computer software for individuals with disabilities and chronic medical conditions RAIL Lab (Research and Innovation in Learning) The RAIL lab is recruiting. For more information, visit the RAIL lab homepage: https://coe.uga.edu/research/labs/rail/. Read more about Matthew Schmidt
Cassandra Hall Assistant Professor of Computational Astrophysics, Department of Physics and Astronomy Dr. Hall is a computational astrophysicist who studies exoplanet formation. Her approach combines machine learning techniques with hydrodynamical simulations of protoplanetary accretion discs to uncover forming exoplanets hidden in telescope data. Dr. Hall leads a team focused on refining these techniques to increase our fundamental understanding of the planet formation process. Education: PhD in Astronomy, University of Edinburgh. MPhys (HONS) Physics & Astrophysics, University of Sheffield. Research Research Interests: Thousands of new worlds beyond our own solar system have been discovered, revealing a hugely diverse exoplanetary architecture. Exoplanets form in evolving protoplanetary accretion discs. The conditions in these discs decide the final mass and ultimate orbital configuration of their exoplanetary systems, causing diversity in the exoplanet architecture. As exoplanets form, they leave behind signatures of their formation that can be detected in interferometric mm observations, such as rings and spirals. In order to try and measure the mass of these forming in planets inside their nascent discs, we typically perform around 100 dusty fluid simulations for each observed system, and try to get the mass this way. However, this is incredibly inefficient, inaccurate, and profoundly limits the regions of parameter space we can explore. At UGA, I am building a research group that will move past this outdated model by harnessing the power of machine learning and information extraction. We are developing neural network techniques that are widely applicable, user-friendly, and around 10,000 times more computationally efficient than current approaches to determining exoplanet mass in forming systems. Of note: Fellow of the Royal Astronomical Society, 2021 Royal Astronomical Society Winton Award for Early Achievement in Astronomy, 2021 Lilly Teaching Fellow, University of Georgia, 2021-2023 Winton Exoplanet Fellowship, 2018-2020 STFC PhD Scholarship, 2013-2017 Read more about Cassandra Hall